tissuescience-dummy-2019

Rejuvenation- Fight Aging

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Aging is an accumulation of damage to macromolecules, cells, tissues and organs. If any of that damage can be repaired, the result is rejuvenation. There are at least eight important hormones that decline with age: 1. human growth hormone (HGH); 2. the sexual hormones: testosterone or oestrogen/progesterone; 3. erythropoietin (EPO); 4. insulin; 5. DHEA; 6. melatonin; 7. thyroid; 8. pregnenolone. In theory, if all or some of these hormones are replaced, the body will respond to them as it did when it was younger, thus repairing and restoring many body functions. In line with this, recent experiments show that heterochronic parabiosis, i.e. connecting the circulatory systems of young and old animal, leads to the rejuvenation of the old animal, including restoration of proper stem cell function. Stem cell regenerative medicine uses three different strategies: 1) Implantation of stem cells from culture into an existing tissue structure, 2) Implantation of stem cells into a tissue scaffold that guides restoration, 3) Induction of residual cells of a tissue structure to regenerate the necessary body part.