Tissue Engineering and Regenerative Medicine

We proposed a new model of optic nerve damage in glaucoma, the model of venous neurovascular pathways to neuroinflammation in glaucoma, based on the theory that glaucoma is a neurodegenerative disorder and optic nerve is amenable to damage imposed by factors affecting the central nervous system. Percutaneous venous transluminal angioplasty appears to be effective and feasible with a high degree of procedural success. PVTA seems to positively influence the clinical status by improving the mean deviation (MD).The results are encouraging and bring promise of a safe and effective approach to adjustment therapeutic approach for patients with chronic open angle glaucoma and moderate to severe visual field defects, with intraocular pressure controlled in the low teens. However, randomized controlled trials will be needed to provide true efficacy and safety data, to convince the clinicians and to become a more high level, evidence-based guideline recommendation.