Tissue Engineering and Regenerative Medicine

Organ-on-Chip technology, the pairing of micro-engineered human tissue with micro-engineered environments, enables the in vitro emulation of human physiology. Our goal is in particular to recapitulate individual organ functions and organorgan interactions, with the goal of elucidating their role in homeostasis, metabolism, development, toxicology and disease. Using computational design studies and working closely with collaborators in academia, industry, and the clinic, we develop micromechanical environments and quantitative readouts specific to particular organs and disease states. This study presents designs and applications of microengineered systems, including the Small-Airway-Chip and the Thrombosis-Chip. In the near future, we aim to study inter-organ signaling and cell migration involved in systemic processes such as cancer, immune-system responses and hormone-mediated remodeling.