Massimiliano Colombo
University of Milan
Italy
Title: Treatment of AVN using the chamber induction technique and biotechnologies: Indications and clinical results
Biography
Biography: Massimiliano Colombo
Abstract
Objective: to determinate the efficacy of core decompression technique with the use of recombinant morphogenetic proteins, autologous mesenchimal stem cells (MSCs) and xenograft bone substitute into the necrotic lesion of the femoral head on clinical symptoms and on the progression of osteonecrosis of the femoral head. Methods: we studied 38 patients and 40 hips with early stages of osteonecrosis of the femoral head. Results: Core decompression technique with the use of recombinant morphogenetic proteins, autologous MSCs and xenograft bone substitute afforded a significant reduction in pain and in joint symptoms and reduced the incidence of fractural stages. At 34 months, 33 patient reach the clinical and radiographic healing. Conclusion. This long term follow-up study confirmed that core decompression technique with the use of recombinant morphogenetic proteins, autologous MSCs and xenograft bone substitute might be an effective treatment for patients with early stages of osteonecrosis of the femoral head.
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