Joseph Purita
Institute of Regenerative and Molecular Orthopedics
USA
Title: Lipogems a game changer in the field of re-generative stem cell therapy
Biography
Biography: Joseph Purita
Abstract
The use of adipose tissue has taken on increasing im-portance in the field of regenerative stem cell therapy. This therapy can be divided into two major pathways. One path-way involves plastic and reconstruction surgery. The other major pathway involves orthopedics and its related fields. Other uses are being found in gynecology, urology, and general surgery. Until recently the main uses of adipose tissue centered around the use of enzymatic produced SVF suspensions. Typically these suspensions were made with the use of the enzyme collagenase. Although collagenase has worked well in the past there is now a complaint method of producing a fast, enzyme free lipoaspirate that is turned into a therapeutic product. This new method comes from the Lipogems company. The Lipogems technique has been utilized in over 5,000 patients. It has recently obtained FDA clearance. Lipogems makes use of the high stem cell density of adipose tissue thought to be 1 out of every 100 cells. Lipogems utilizes mild mechanical forces in a closed system to produce micro fractured and purified adipose tissue graft which is non ex-panded and ready to use in a variety of regenerative appli-cations. More importantly, Lipogems adipose product has a very well preserved vascular stroma with slit-like capillaries wedged between adipocytes and and vascular channels. The stem cell niche is preserved enabling the pericytes to have a much higher survivability rate. The intact niche pro-vides a perfect environment for reparative response of acti-vated MSCs. As Dr. A. Caplan has pointed out, pericytes are precursor mesenchymal stem cells. Activated MSCs are crucial for the immune modulation and regeneration. The lipoaspirate of Lipogems shows a higher percentage of ma-ture pericytes and hMSCs than enzymatically digested lipoaspirates. We are now aware that there are novel growth factors secreted by Lipogems lipoaspirate which may explain the therapeutic efficacy of Lipogems. Also im-portant, is the fact that the Lipogems technique may pre-serve the important MUSE cell. Muse cells are unique in that they be pluripotent, have a high survivability rate, and are quite small by stem cell standards. They are considered to be an embryonic like stem cell without any of the risks of regular embryonic stem cells since they are the patient's own. They may represent a quantum leap in regenerative medicine. Since Lipogems preserves these cells it too is a quantum leap.
