10th International Conference on Tissue Science and Regenerative Medicine
Tokyo, Germany
Khorshid Ghazimoradi
Islamic Azad University, Iran
Title: Muscle regeneration mechanism from Pluripotent stem cells
Biography
Biography: Khorshid Ghazimoradi
Abstract
Pluripotent stem cells are most accessible cells for regenerative medicine. This source of cells has been used in many different clinical trials for regeneration of tissues and organs from skin, kidney, eyes and many other examples. In here, we with helping of bioinformatics, investigate RNA-seq data and study the underlying mechanism of differentiation of iPScs in treatment of duchenne diseases. For this proposes the transcriptome analysis of cells after injection to duchenne muscular dystrophy patients has been determined. Furthermore, the data have been analyzed by us and its heat map1 and network2 has been established and relative mechanism has been discovered. Our analysis shows that after differentiation of iPScs several mechanisms will be activated which is consistent of biosynthesis of amino acids and protein construction. This process also activated degeneration pathway of proteins. In addition many of phagocytosis and lysis pathways have been activated. This data show not only iPScs can generate new myogenesis and myotube cells with an upregulation in protein synthesis, it also help destruction of previous structures which hinder the function of muscles.