Mahmoud Saeed Mahmoud
Al-Azhar University, Egypt
Title: Role of Serum Glypican 3 among Egyptian patients with Hepatocellular Carcinoma
Biography
Biography: Mahmoud Saeed Mahmoud
Abstract
Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies worldwide and one of the main causes of cancer-related mortality globally. Its incidence is increasing at alarming rates. The presence of cirrhosis is the major risk factor and this is largely due to chronic HCV and HBV infection. Serum alpha-fetoprotein (AFP) has insufficient sensitivity and speciï¬city for detection of hepatocellular carcinoma (HCC). Estimation of serum level of certain up regulated proteins as glypican-3 (GPC-3) in HCC could be a promising biomarker for screening and early HCC detection. Recently glypican-3 (GPC-3) was suggested as a novel biomarkers for the detection HCC.