Neelima Mishra
Sanskriti University, India
Title: Biological potent heteroaryl ketone Schiff base and thorium(IV) complexes of 2-benzoaminothiazole
Biography
Biography: Neelima Mishra
Abstract
Metal-based antioxidants has received effort in order to identify the compounds having high free radical scavenging capacity related to various disorders and diseases associated with oxidative damage due to reactive oxygen species (ROS). Two mononuclear Th(IV) complexes were derived from 2,3–dihydro–1H–indolo[2,3–b]phenazine–4(5H)–ylidene)benzothiazole–2–amine (L1) and 3–(ethoxymethylene)–(2,3–hihydro–1H–indolo[2,3–b]phenazine–4(5H)–ylidene)benzothiazole–2–amine (L2) with properties of pharmacologically interest. The compounds were characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, FTIR, UV-Vis, 1H NMR, TGA and XRD studies. In both complexes 2:1 ligand-to-metal ratio has been observed. Ligands and metals complexes showed antimicrobials and antioxidants activities. Antioxidant property is shown by DPPH and H2O2 Scavenging methods. Antimicrobial activities against E. coli, S. aureus bacteria and C. tropicalis, A. niger by test tube method.