Tissue Repair and Regeneration

Tissue repair and regeneration following injury or disease are often thought to recapitulate embryonic development by using similar molecular and cellular pathways. In addition, many embryonic tissues, such as the spinal cord, heart, and limbs, have some regenerative potential and may utilize mechanisms that can be exogenously activated in adult tissues. For example, BMP signaling regulates nervous system development, and SMAD reactivation plays a critical role in adult nerve regeneration and repair in animal models of spinal cord injury. While similar molecular pathways are utilized during embryogenesis and adult tissue regeneration, recent reports suggest the mechanisms by which these developmental programs are reactivated and maintained may vary in adult tissues. Adult fish and amphibians have a remarkable capacity for tissue regeneration, while mammals have a limited regenerative capacity.

  • Prosthodontics and endodontics
  • Peridontal therapy/surgery
  • Effects of guided tissue regeneration
  • Advancements in biomedical and tissue engineering techniques
  • Recent innovations in regenerative and tissue engineering
  • Advanced stem cell therapies in tissue engineering

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