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8th International Conference on Tissue Science and Regenerative Medicine, will be organized around the theme “Explore and Exploit the Novel Techniques to Repair, Restore and Regenerate”

Tissue Science Congress 2017 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Tissue Science Congress 2017

Submit your abstract to any of the mentioned tracks.

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Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological tissues. Tissue engineering involves the use of a scaffold for the formation of new viable tissue for a medical purpose. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own. While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.

  • Track 1-1Musculoskeletal tissue regeneration
  • Track 1-2Cardiovascular tissue regeneration
  • Track 1-3In-situ tissue regeneration
  • Track 1-4Tissue biomarkers
  • Track 1-5 Tissue graft tolerance
  • Track 1-6Tissue mechanics and mechanobiology

Research in the Biomaterials and Tissue Engineering track involves the investigation and development of materials and structures to improve the quality of life for patients. These materials—which may be synthetic, natural, or cell-based—are intended to assist in the diagnosis of pathology or injury, monitor condition, and improve or restore normal physiological function in the human body. Biomaterials science is the study of materials and their interaction with biological environments, and tissue engineering is the application of engineering and life sciences toward development of a biomaterial to restore, maintain and improve tissue function. Research in this inter- and multidisciplinary field involves collaborations among engineers, surgeons, materials scientists, biological scientists, chemists, dentists, and veterinarians in academics, industry, government and the clinic.

  • Track 2-1Myocardial tissue engineering
  • Track 2-2Orthopedic and musculoskeletal medicines
  • Track 2-3Strategies for skin tissue regeneration
  • Track 2-4Drug eluting stents

Regenerative medicine is the branch of medicine that develops methods to regrow, repair or replace damaged or diseased cells, organs or tissues. Regenerative medicine includes the generation and use of therapeutic stem cells, tissue engineering and the production of artificial organs. Regenerative medicine seeks to replace tissue or organs that have been damaged by disease, trauma, or congenital issues, vs. the current clinical strategy that focuses primarily on treating the symptoms. The tools used to realize these outcomes are tissue engineering, cellular therapies, and medical devices and artificial organs.

  • Track 3-1Medical Devices and Artificial Organs
  • Track 3-2Cellular Therapies
  • Track 3-3Regenerating a new kidney
  • Track 3-4Clinical Translation

Stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.Stem cells are distinguished from other cell types by two important characteristics. First, they are unspecialized cells capable of renewing themselves through cell division, sometimes after long periods of inactivity. Second, under certain physiologic or experimental conditions, they can be induced to become tissue- or organ-specific cells with special functions. In some organs, such as the gut and bone marrow, stem cells regularly divide to repair and replace worn out or damaged tissues. In other organs, however, such as the pancreas and the heart, stem cells only divide under special conditions.

  • Track 4-1Embryonic stem (ES) cells
  • Track 4-2 Adult stem cell
  • Track 4-3Induced Pluripotent Stem Cells
  • Track 4-4Tissue stem cells
  • Track 4-5Application of stem cell

Tissue engineering along with regenerative medicine can be used to create ‘Scaffolds’ in the human body. These scaffolds are used to support organs and organ systems that may have been damaged after injury or disease. So what is tissue engineering? ‘Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physico-chemical factors to improve or replace biological functions’. This is most commonly achieved through the use of stem cells. Stem cells are unique types of cells that are undifferentiated. So the main focus of creating these constructs is to be able to safely deliver these stem cells, and create a structure that is physically and mechanically stable so that these stem cells can differentiate. Scaffolds are of great importance in clinical medicine. It is an upcoming field, and usually associated with conditions involving organ disease or failure. It is used to rebuild organs and return normal function.

  • Track 5-1Scaffold designs
  • Track 5-2Fabrication of scaffolds
  • Track 5-3Biodegradable nanofiber scaffolds
  • Track 5-4D scaffolds and models
  • Track 5-5Surface ligands and molecular architecture
  • Track 5-6Porous scaffolds

Biobanking play a crucial role in biomedical research. The wide array of bio specimens (including blood, saliva, plasma, and purified DNA) maintained in biobanks can be described as libraries of the human organism. They are carefully characterized to determine the general and unique features of the continuous cell line and the absence or presence of contaminants, therefore establishing a fundamental understanding about the raw material from which the biological product is being derived and maintained. Biobanks catalog specimens using genetic and other traits, such as age, gender, blood type, and ethnicity. Some samples are also categorized according to environmental factors, such as whether the donor had been exposed to radiation, asbestos, or some other substance that can affect human genes.

  • Track 6-1Fertility biobanks
  • Track 6-2Next Generation Biobanking
  • Track 6-3Stemcell Banking
  • Track 6-4Germplasm Bank
  • Track 6-5Data Enrichment in Biobanks

Tissue repair and regeneration following injury or disease are often thought to recapitulate embryonic development by using similar molecular and cellular pathways. In addition, many embryonic tissues, such as the spinal cord, heart, and limbs, have some regenerative potential and may utilize mechanisms that can be exogenously activated in adult tissues. For example, BMP signalling regulates nervous system development, and SMAD reactivation plays a critical role in adult nerve regeneration and repair in animal models of spinal cord injury. While similar molecular pathways are utilized during embryogenesis and adult tissue regeneration, recent reports suggest the mechanisms by which these developmental programs are reactivated and maintained may vary in adult tissues. Adult fish and amphibians have a remarkable capacity for tissue regeneration, while mammals have a limited regenerative capacity.

  • Track 7-1Dental tissue repair
  • Track 7-2Deregulation of normal tissue repair
  • Track 7-3Effects of guided tissue regeneration
  • Track 7-4Organ-Specific Regeneration
  • Track 7-5Cancer, Skin, and the Wound Healing Analogy
  • Track 7-6Epigenetics
Cellular Engineering involves the application of engineering principles to problems in cellular and molecular biology, particularly as they relate to human health. The goal of this track is to equip students with the quantitative tools necessary to understand, manipulate, and control cellular and sub-cellular processes for a range of biomedical applications, including those related to stem cells, tissue engineering, and regenerative medicine.Cellular engineering is a new field that addresses issues related to understanding and manipulating cell structure-function relationships. This course is intended to be a bridge between cell biologists and engineers, to understand quantitatively cell biological aspects. Cellular engineering is intrinsically connected to the new field of tissue engineering. As we embark on approaches to engineer new tissues that have always been considered too difficult for intervention, the use of cells takes an almost central role. For example, if we want to generate the liver, we must first understand what hepatocytes like and how we can modulate their function. In numerous medical applications, we wish to make skeletal tissues regenerate. 
 

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. This controversy is often related to abortion politics and to human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial.

  • Track 9-1Development of regenerative treatment models
  • Track 9-2 Sources of stem cells
  • Track 9-3 Stem cells and hard-tissue repair
  • Track 9-4Stem cells and orthopedic repairs
  • Track 9-5Application of stem cell therapy

There are more than 200 types of cancer, including Breast cancer, skin cancer, lung cancer, colon cancer, Prostate cancer, and lymphoma. Symptoms and Treatment varies depending on the type of Cancer. Some people with cancer will have only one treatment. But most people have a combination of treatments, such as surgery with chemotherapy and/or radiation therapy. The Anticancer therapies include Surgical therapy, Chemotherapy, Adjuvant therapy, Neoadjuvant therapy, Palliative therapy, Immunotherapy, Hormonal therapy, Radiotherapy, Nutritional therapy, Phototherapy. Phototherapy / proton beam therapy is the most advanced among all the therapies. All Anticancer agents act by disturbing cell multiplication or normal functioning, DNA synthesis or chromosomal migration, and by blocking or changing RNA and protein metabolism.

  • Track 10-1Surgical Therapy
  • Track 10-2Chemotherapy
  • Track 10-3Radiation Therapy
  • Track 10-4Cancer Genetics
  • Track 10-5Cancer Immunotherapy

Gene therapy aims to transfer genetic material into cells to provide them with new functions. A gene transfer agent has to be safe, capable of expressing the desired gene for a sustained period of time in a sufficiently large population of cells to produce a biological effect. Identifying a gene transfer tool that meets all of these criteria has proven to be a difficult objective. Viral and nonviral vectors, in vivo, ex vivo and in situ strategies co-exist at present, although ex vivo lenti-or retroviral vectors are presently the most popular.Natural stem cells (from embryonic, hematopoietic, mesenchymal, or adult tissues) or induced progenitor stem (iPS) cells can be modified by gene therapy for use in regenerative medicine.

  • Track 11-1In-vivo gene transfer
  • Track 11-2Ex-vivo gene transfer
  • Track 11-3Gene doping
  • Track 11-4Application of gene therapy
  • Track 11-5Allogeneic Cell Therapy
  • Track 11-6Human embryonic stem cells
  • Track 11-7Mesenchymal Stem Cell Therapy

Immunotherapy is treatment that is designed to harness the ability of the body’s immune system to combat infection or disease. Immunotherapy might produce an immune response to disease or enhance the immune system’s resistance to active diseases such as cancer. Sometimes referred to as biological therapy, immunotherapy often uses substances referred to as biological response modifiers (BRMs). The body usually only produces small amounts of these BRMS in response to infection or disease, but in the laboratory, large amounts of these BRMs can be generated in order to provide a therapy for cancer, rheumatoid arthritis and other illnesses. In cancer immunotherapy, certain parts of the immune system are used to fight cancer in several ways. Some biological therapies are designed to boost the immune system generally, while others help train the immune response to specifically target cancer cells. Immunotherapy may be used alone or in combination with other therapies, depending on the type of cancer a patient has.

  • Track 12-1Cancer immunotherapy
  • Track 12-2Immune enhancement therapy
  • Track 12-3Immune recovery
  • Track 12-4Genetically engineered T cells
  • Track 12-5Immunosuppressive drugs

A stem cell transplant is a treatment for some types of cancer. For example, you might have one if you have leukemia, multiple myeloma, or some types of lymphoma. Doctors also treat some blood diseases with stem cell transplants.In the past, patients who needed a stem cell transplant received a “bone marrow transplant” because the stem cells were collected from the bone marrow. Today, stem cells are usually collected from the blood, instead of the bone marrow. For this reason, they are now more commonly called stem cell transplants.A part of your bones called “bone marrow” makes blood cells. Marrow is the soft, spongy tissue inside bones. It contains cells called “hematopoietic” stem cells. These cells can turn into several other types of cells. They can turn into more bone marrow cells. Or they can turn into any type of blood cell. Certain cancers and other diseases keep hematopoietic stem cells from developing normally. If they are not normal, neither are the blood cells that they make. A stem cell transplant gives you new stem cells. The new stem cells can make new, healthy blood cells.

  • Track 13-1Autologous stem cell transplant
  • Track 13-2Cord blood stem cell transplant
  • Track 13-3Embryonic stem cell transplant
  • Track 13-4Hematopoietic stem cell transplantation

Tissue culture, a method of biological research in which fragments of tissue from an animal or plant are transferred to an artificial environment in which they can continue to survive and function. The cultured tissue may consist of a single cell, a population of cells, or a whole or part of an organ. Cells in culture may multiply; change size, form, or function; exhibit specialized activity (muscle cells, for example, may contract); or interact with other cells.

  • Track 14-1Plant tissue culture
  • Track 14-2Animal tissue culture
  • Track 14-3Tissue culture techniques
  • Track 14-4Application of tissue culture

The tremendous need for bone tissue in numerous clinical situations and the limited availability of suitable bone grafts are driving the development of tissue engineering approaches to bone repair. In order to engineer viable bone grafts, one needs to understand the mechanisms of native bone development and fracture healing, as these processes should ideally guide the selection of optimal conditions for tissue culture and implantation. Engineered bone grafts have been shown to have capacity for osteogenesis, osteoconduction, osteoinduction and osteointegration - functional connection between the host bone and the graft. Cells from various anatomical sources in conjunction with scaffolds and osteogenic factors have been shown to form bone tissue in vitro. The use of bioreactor systems to culture cells on scaffolds before implantation further improved the quality of the resulting bone grafts. Animal studies confirmed the capability of engineered grafts to form bone and integrate with the host tissues. 

  • Track 15-1 Principles of Bone and Cartilage Reconstruction
  • Track 15-2Cell sources for bone and cartilage tissue engineering
  • Track 15-3Osteogenic signaling factors
  • Track 15-4 Chondrogenic signaling factors
  • Track 15-5Design and fabrication of 3-D scaffold
  • Track 15-6Using stem cells to build new bones

Researchers are expanding their understanding of identified adult stem cells, which include blood-forming, brain, skin and skeletal muscle stem cells, while working to isolate stem cells for the lung, liver, kidney, heart and other tissues. This work is providing the basis for ongoing preclinical and clinical trials of organ and tissue regeneration from healthy adult stem cells.With the capability of self-renewal, pluripotency and differentiation, stem cells have been believed to be useful for treatment of a wide variety of diseases in the future, including stroke, traumatic brain injury, Alzheimer’s disease, Parkinson’s disease, spinal cord injury, baldness, blindness, deafness, wound healing, amyotrophic lateral-sclerosis, myocardial infarction, muscular dystrophy, osteoarthritis rheumatoid arthritis, Crohn’s disease, and diabetes. Amongst the applications, a number of adult stem cell therapies have already been practiced clinically. As an example, hematopoietic stem cell transplantation has been successfully applied to treat leukemia. In addition to cell replacement therapy using stem cells, organ transplantation has been successfully practiced in clinics for organ failure of the liver or kidney

Translational science aims to apply biomarkers discovered in preclinical research for predicting potential clinical outcomes. At the same time, data generated in clinical trials can be used to enhance early stage discovery by suggesting potential safety and efficacy tests for animal models and in vitro experiments. Translational research relies on a continuous stream of knowledge between multiple silos and disciplines that requires close monitoring and consistent semantics. The systems biology approach developed by Thomson Reuters provides integrated databases and comprehensive tools well suited for translational research.

  • Track 17-1Biomarkers in Translational Medicine
  • Track 17-2Data Management and Data Mining Approaches
  • Track 17-3Drug Development Process
  • Track 17-4Case Studies and Reports

Aging is an accumulation of damage to macromolecules, cells, tissues and organs. If any of that damage can be repaired, the result is rejuvenation. There are at least eight important hormones that decline with age: 1. human growth hormone (HGH); 2. the sexual hormones: testosterone or oestrogen/progesterone; 3. erythropoietin (EPO); 4. insulin; 5. DHEA; 6. melatonin; 7. thyroid; 8. pregnenolone. In theory, if all or some of these hormones are replaced, the body will respond to them as it did when it was younger, thus repairing and restoring many body functions. In line with this, recent experiments show that heterochronic parabiosis, i.e. connecting the circulatory systems of young and old animal, leads to the rejuvenation of the old animal, including restoration of proper stem cell function. Stem cell regenerative medicine uses three different strategies: 1) Implantation of stem cells from culture into an existing tissue structure, 2) Implantation of stem cells into a tissue scaffold that guides restoration, 3) Induction of residual cells of a tissue structure to regenerate the necessary body part.

  • Track 18-1PQQ: Reverse Cellular Aging
  • Track 18-2Protection Against Brain Aging
  • Track 18-3Stem Cell Therapies Produce Rejuvenation
  • Track 18-4Applications of Rejuvenation

“Regenerative medicine” describes a set of innovative approaches to the treatment of illness, injury, and disability, focusing on the growth, replacement, and repair of cells, organs, and tissues specific to the health needs of particular individuals. The extraordinary breadth of application of this approach is clear from an enumeration of just a few areas of regenerative medicine research, such as stem cells, including embryonic stem cells, pluripotent stem cells produced by genetic reprogramming, and multipotent stem cells from non-embryonic tissues; techniques for stimulating endogenous cell growth and repair for the kidney and pancreas in diabetes, or for digits and limbs injured as a result of trauma; and the growth of replacement tissues and organs, for example, blood vessels, hollow organs like the bladder, and even solid organs like the heart. This enormous diversity of applications, all currently in various stages of research and development, stems from a multidisciplinary research orientation incorporating genetics, informatics, basic research into the structure, mechanics, and development of different tissues, and creative production techniques. Despite its enormous promise, however, at this time regenerative medicine’s many applications constitute a very early step along the road to effective treatments.

There are strong pricing pressures from public healthcare payers globally as Governments try to reduce budget deficits. Regenerative medicine could potentially save public health bodies money by reducing the need for long-term care and reducing associated disorders, with potential benefits for the world economy as a whole. The global market for tissue engineering and regeneration products reached $55.9 billion in 2010, is expected to reach $59.8 billion by 2011, and will further grow to $89.7 billion by 2016 at a compounded annual growth rate (CAGR) of 8.4%.  It grows to $135 billion to 2024.

  • Track 20-1Regenerative medicine research in World
  • Track 20-2Human Tissue Market in Asia
  • Track 20-3Tissue analysis products Market in USA
  • Track 20-4Stem cell analysis products Market in UK